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The phrase "a genuine breakthrough" is correct and usable in written English.
It can be used to describe a significant and authentic advancement or discovery in a particular field or context.
Example: "The researchers announced a genuine breakthrough in cancer treatment that could save countless lives."
Alternatives: "a true advancement" or "an authentic innovation".
Exact(33)
If perfected, this would be a genuine breakthrough.
With luck, a genuine breakthrough might occur: perhaps advances in electric batteries or storage.
So, in some quarters, anticipation of a genuine breakthrough is rising.
What could have been a genuine breakthrough then turned into another downward spiral.
Now they have a chance to make a genuine breakthrough into American rock awareness.
Unless there is a genuine breakthrough in the coming months, more Israelis will be inclined to agree.
Similar(27)
Several ideas were fully or partially implemented, (with hundreds of millions of USD invested), with a couple of genuine breakthrough successes, and hundreds of related patents were filed.
But DeepMind did hit upon a few genuine breakthroughs.
Swedish Foreign Minister Carl Bildt, of the rival Moderate Party joked: "Congratulations - finally, after all these years you have made a genuine public breakthrough".
It will be a very small screen for a laptop seven and a half inches but if it works, it will represent a genuine engineering breakthrough.
On a small lot between Houston and the Gulf Coast, in an industrial zone packed with petrochemical factories and gas pipelines, a little-known company is finalizing construction of a demonstration power plant that could represent a genuine energy breakthrough.
More suggestions(15)
a realistic breakthrough
a genuine turnaround
a genuine revelation
a substantial breakthrough
a genuine accomplishment
a genuine leap
a genuine breach
a genuine achievement
a genuine triumph
a legitimate breakthrough
a genuine milestone
a serious breakthrough
a genuine progress
a genuine turning point
a true breakthrough
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com