Then, a second-order Generic factor would affect the first-order NF, PF, CP, SP, PN, FG and SA factors, and the other second-order cancer-specific factor would affect AC, FP, DOR and FRD first-order factors [ 5].
However, whether ERCC1 is simply a generic prognostic factor or a specific predictor of cisplatin efficacy is still to be demonstrated.
Retention of a generic 'transcription factor activity' does not make sense in the MF ontology because from a MF viewpoint it is equivalent to an otherwise unknown MF that regulates transcription.
Some of the first models were differential equations representing a generic growth factor as a chemotactic stimulus, produced and released by a tumor mass, and inducing growth of vessels into the tumor [ 14- 16].
A generic RBE factor of 1.1 has been used at the Harvard Cyclotron, Northeast Proton Therapy Center, Loma Linda University, Paul Scherrer Institute in Switzerland, Orsay in France, and Faure in South Africa, while Tsukuba in Japan and Uppsala in Sweden have used 1.0.
This intervention is based on acceptance and commitment therapy (ACT; [ 44]) and mindfulness [ 45, 46], and targets experiential avoidance that can be considered as a generic risk factor for mental illnesses [ 47].
We applied the Rasch method to the Generic factor, the Cancer-specific factor, and the BOC factor separately, to ensure that the scales were unidimensional [ 24] as this is a fundamental requirement for construct validity.
Based on the results of Rasch analyses, we propose a model in which four items were deleted (items 22 and 28 from PF and items 15 and 25 from SA), and the second-order generic factor would not affect the SP first-order factor, and the second-order specific factor would not affect the FP first-order factor.
(The assumption here is that the default state of the CpG island in sperm is hypomethylation and that, as a CpG island, generic factors would tend to maintain the hypomethylated state of the paternally-derived allele in the embryo).
