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Our data demonstrate cardiac mitochondrial oxidative stress and development of a hypertensive gene expression pattern in WKY rats, characterized by a generalized suppression of genes that are already suppressed in SH rats at baseline without DE.
Taken together, these results suggest that while the expressions of IFN-λ2 and, especially of IFN-β proteins, were profoundly inhibited, SARS-CoV infection did not impose a generalized suppression of host posttranscriptional machinery in 2B4 cells, an observation consistent with that reported for SARS-CoV nsp-1 protein [12], [64].
A generalized suppression of hematopoiesis might occur after RYGB and explain some of the phenomena [ 16].
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EEG-patterns that are strongly associated with a poor outcome after cardiac arrest and considered "malignant patterns" include a generalized suppression to <20 µV, burst-suppression pattern with generalized epileptiform activity, or generalized periodic complexes on a flat background [163].
EEG-patterns that are strongly associated with a poor outcome after cardiac arrest and considered "malignant patterns" include a generalized suppression to <20 µV, burst-suppression pattern with generalized epileptiform activity, or generalized periodic complexes on a flat background [ 163].
In the SCPI-treated larvae, there was a significant reduction of [H]-palmatic acid levels (F2,9 = 15.15, p = 0.0013) in the midgut tissue except at the 4 hour time point in the SCPI-2 treated group (Fig. 6A), suggesting that there was a generalized suppression in the uptake of free fatty acid from the midgut lumen into the midgut tissue in SCPI-treated larvae.
This is an important finding as it suggests that LC activation does not elicit a global and generalized suppression of synaptic transmission in the CA1 region.
The generalized suppression of immunity in gravid animals late in gestation is often cited as a factor in increased disease susceptibility [10], [12].
The immune dysfunction in the draining LN due to local IDO expression in DC is not indicative of a generalized immune suppression in cancer patients.
It is worth noting that a single EEG with complete generalized suppression in comatose survivors after cardiac arrest indicates no possibility of recovery in the level of consciousness [44].
To investigate whether lack of immune response against Tag in aged TRAMP and TRAMPJα18−/− mice reflected a generalized immune suppression or was specific for the TAA, cohorts of TRAMP, TRAMPJα18−/− and WT mice were immunized with DC pulsed with the unrelated and Kb-restricted melanoma antigen TRP-2.
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