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Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in energy homeostasis.
This YAP driven increase in proliferation occurs in a number of different developing murine tissues, suggesting a generalized role of YAP to promote cellular proliferation in mammalian cells [46, 47].
Further work is needed to fully understand the subunit composition of BAM holo-complexes, but the evidence so far suggests a generalized role for OmpA-domain proteins in anchoring the BAM complex to the peptidoglycan layer of diverse Gram negative bacteria.
This suggests the existence of a core network in the brain that plays a generalized role in interoceptive processing.
This suggests that it may play a generalized role in ESC transcription, particularly when considered with evidence that Esrrb interacts physically with components of the basal transcriptional machinery (van den Berg et al., 2010).
These observations prompted us to test whether endotrophin plays a critical role in the cisplatin-driven increase of EMT, as endotrophin plays a generalized role in EMT in tumour tissues (Park & Scherer, 2012b).
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A number of experiments were conducted to evaluate if Akt1 was required for the localization of specific postsynaptic proteins, or rather served a more generalized role in directing a variety of proteins to this membrane specialization.
Its isoforms, which are created by alternative promoters and alternative splicing, have divergent abilities to transactivate p53 reporter genes and induce apoptosis [33] (suggesting a more generalized role).
This data suggests that the GPNMB/OA may play a more generalized role in promoting tumor progression, but does not preclude the possibility that certain GPNMB/OA-related functions specifically favor the development of bone metastases.
The effectiveness of the LT-IFN pathway against two distinct pathogens suggests a more generalized role in host defense.
Lam et al. [ 65] suggested a more generalized role of palmitoylation in the ER quality control of polytopic membrane proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com