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This supports an influence of serotonin on motor neuron generation, but not a generalized effect on spinal neurogenesis.
This suggests that this regulation does not reflect a generalized effect of RA.
Thus, the HCV-induced suppression of TLR9-mediated IFN-α secretion is not due to a generalized effect of HCV on TLR signaling in pDCs.
We found that indeed expression levels and primary transcript length were negatively correlated (e.g. oligo-array DS-I: r = −0.142 n = 14236 P<0.0001) and this was common to almost every transcript component indicating the presence of a generalized effect.
Interestingly, under these conditions, RelA mRNA levels remained unchanged, suggesting that the Tat-mediated increase in RelB was not a generalized effect of Tat on NF-κB subunits (Figure 1).
To further investigate whether the increase in the density of VGAT and VGLUIT2 terminals is restricted to the terminals apposing/contacting GnRH neurons only or is a generalized effect in the area in close vicinity of GnRH neurons, we counted the total number of VGAT and VGLUT2 positive terminals in the close vicinity of GnRH neurons.
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A more generalized effect of paternal age on immune function seems plausible.
These results are not due to a more generalized effect on basal dendrite branching, as Sholl analysis demonstrated no significant changes in dendritic arbor complexity between control and experimental conditions (data not shown).
Given the links between paternal age, neurodevelopomental disorders, and immune function, it seems that paternal age might also have a more generalized effect on immune function as it was found to have on neurodevelopment.
It is unknown, therefore, whether temperature may have a more generalized effect on the starvation response of L. hongkongensis.
For the gene ZK795.3, which showed a more generalized effect on the development, corresponding widespread expression pattern was observed in the worm and in human cell lines.
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