Sentence examples for a generalized defect from inspiring English sources

It is important to note that FRDA cells do not have a generalized defect in CTCF binding14.

However, the inability of PTH and hypophosphatemia to stimulate enzyme activity in a manner analogous to that in normal and phosphate-depleted mice indicates that a generalized defect of 1 alpha-hydroxylase regulation is manifest in Hyp-mice.

It is also significant that epididymal fat showed a similar pattern (Figure 3) suggesting a generalized defect in adipose development.

Again, this did not reflect a generalized defect in cellular calcium handling since TCR engagement induced comparable Ca2+ signaling in purified CD83Tg and wild-type T cells.

The analysis of cytokines in the culture supernatant revealed increased IL-10 secretinn in LPS activated CD83Tg spleen cell cultures compared to wild-type spleen cell cultures (figure 3D), arguing against a generalized defect in CD83Tg lymphocytes.

Next, to determine if the reduced ability of SP thymocytes to produce TNF was due to a generalized defect in their activation, we examined the expression of activation markers CD25, CD69, CD44 and CD62L on the P14-CD8+ SP thymocytes and splenic T cells.

We were curious to know if the elongation defect in exocyst mutants was restricted to the elongation zone, or if it represented a more generalized defect (for example, a defect altering the basic structure and overall expansibility of the cell wall) that also influenced cell elongation in the meristem.

We cannot exclude that this might reflect a more generalized defect in the splicing machinery with increased aging.

P63 deficient mice display a striking generalized defect in stratified epithelium, indicating crucial roles in maintaining stem cell populations in squamous and other stratified epithelia (Yang et al, 1999).

It was surprising that SPCS1 and SPCS2 mutations only impacted cell surface staining of ULBP1 and not the six other membrane proteins tested, as we had expected that mutating components of the signal peptidase complex would cause a more generalized defect in cell surface protein expression (see 'Discussion').

To see if our observation was specific to AJM-1 or reflected a more generalized defect in the epithelia of pha-1 (0 ) mutants, we examined expression patterns of several markers associated with adherens junctions and integrity in 1.5-fold pha-1 (0 ) embryos.