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We find that chimeric forms of Notch, in which both the extracellular sensor module and the intracellular transcriptional module are replaced with heterologous protein domains, can serve as a general platform for generating novel cell-cell contact signaling pathways.
Using the combined toxicity of suppressor tRNA toward the host with blue white selection, we developed a convenient screening system for orthogonal suppressor tRNA that could serve as a general platform for generating tRNA/aaRS pairs and thereby obtained three suppressor tRNA mutants with high orthogonality from the tRNA library derived from Mj tRNATyr.
This approach also provides a general platform for programmed responses to other complex cell states.
It thus enables a general platform for antibody tagging with Cu-64.
This developed method might be applied as a general platform for indirect detection using LC/MS analysis.
This can provide a general platform for multipurpose sensing of different types of gases in a reusable fashion.
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Without the need of a complicated and rigorous architecture for precise distance control, full-coupling SPCE offers great promise for a general platform of chip-based biosensing and bioanalysis.
Along the way, he realized what he wanted was really a more general platform for curating anything he found on the web.
Finally, being encouraged by the positive feedbacks from both medical staffs and elders, we are also planning to further develop our system as a more general platform for visualizing medical metadata.
The strategic advances achieved with this pathway have substantially expanded the power and flexibility of ICC as an increasingly general platform for small-molecule synthesis.
We hypothesized that +36 GFP may also serve as a potent and general platform for the delivery of proteins into mammalian cells.
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