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A general issue in exploiting such approach concerns the breadth of the population that can be reached by serious games.
A general issue in data analysis is the relationship between the neurobiological hypothesis one posits and the statistical models adopted to test that hypothesis.
A general issue in understanding the mechanisms underlying the great variety of BMP inductive and tropic activities in the developing and mature organism is that of how a large number of BMPs act through a restricted number of BMP receptors to give rise to many different outcomes.
Polymorphism in bulk phases is a general issue in several fields, including pharmaceuticals and materials science.
A general issue in recombinant production of active hemoproteins is heme availability.
A general issue in density estimation using constant intervals (categories) is that some intervals may contain very little data while others are well represented in the analyzed data set [ 40].
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If this happens elsewhere in your home it could be a general issue; if it is in just one room, a local one.
This is a general issue related to power structures in the media industries.
We therefore think that mentioning such a caveat as a general issue would misrepresent the data in the paper.
Reviewer #1: A general issue of very broad interest in biomedical science is how RGS proteins regulate the kinetics of GPCR signaling.
Trust, then, is a much more general issue in health systems and in pharmaceuticals supply chains in particular than has so far been addressed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com