There was a general dose-related reduction in neutrophil count during treatment with sarilumab (figure 4A).
Lipegfilgrastim PK results demonstrated a general dose-dependent increase in drug exposure, reflected by increasing Cmax and AUC values with increasing dose.
One group comprised of genes showing a general dose-dependent increase with respect to copper, and two groups displayed the converse relationship being separated by the degree of down-regulation observed in the two lower copper doses.
Long-term observational studies [ 13, 14] and numerous systematic reviews and meta-analyses of controlled trials have shown significant risk factor reductions following various types of PA interventions in a general dose-response pattern [ 15, 16].
In conclusion, this study confirmed that cigarette smoking is significantly associated with higher risk of NSCLC having hypermethylation of p16, DAPK or RARβ promoter, and a general dose-response trend was confirmed.
Therefore, as a general principle, dose levels should be selected as those doses where variations in the parameters result in the largest possible changes of the resulting response.
We investigated the effects of a general anesthetic dose of propofol on levels of phosphorylated tau in the mouse hippocampus and cortex under normothermic conditions.
The present study expands on these findings by demonstrating the effects of a general anesthetic dose of a more clinically-utilized anesthetic at clinically relevant time intervals: 30 min and 2 h following anesthesia.
Given the recent findings by Run et al. [18], we investigated whether a general anesthetic dose of propofol would increase the phosphorylation of tau in the absence of hypothermia.
