Frailty is a term describing a state of general debility associated with decline, disability, loss of independence, susceptibility to iatrogenic complications, and poor health outcomes [ 3, 4].
Three explanations for the findings were considered: an immunodepressive effect of general debility, an immunodepressive effect specific to cancer and, on the other hand, the occurrence of cancer preferentially in individuals with an impaired capacity for antibody production.
Endogenous factors: age over 65 years, obesity, nicotine and alcohol abuse, diabetes, vascular diseases, immunosuppressive therapy, cancer or general debility may lead to a suppression of the cellular and humoral resistance to infection [16].
The treatment of Brucella, a disease which produces abortion in cattle and general debility in man, involved many of their successes.
Thiamin deficiency results in beriberi, a disease characterized by multiple neuritis (lesions of nerves), general debility, and heart failure.
The inferior participation in the youngest and oldest age groups, as also seen in other studies (UK Colorectal Cancer Screening Pilot Group, 2004; Denis et al, 2007; Pornet et al, 2010), may be caused by a minor level of perceived threat of cancer in the former, and a perception that the benefits are small in the elderly, maybe struggling with general debility and comorbidities.
They may also irritate the upper respiratory tract, causing coughing, choking, and general debility.
A Pennsylvania chaplain noted a peculiar reason that two men in the regiment claimed for a discharge: "Both of them have been married for some years; and yet such are the pernicious effects of the early indulgences, that now they frequently have nocturnal emissions, foul dreams, etc. — besides rheumatism and general debility — such as renders them unfit for service".
The papaya bark, leaf, and fruits are being used as medicines to treat several diseases such as amenorrhoea, general debility, constipation, corns, cutaneous tubercles, warts, sinuses, eczema, glandular tumours, blood pressure, diabetes, malaria, expel worms, gonorrhoea, and syphilis (Aravind et al. 2013; Sinhalagoda et al. 2013; Rashed et al. 2013).
Depression in the elderly can coexist and be easily confused with dementia and general debility due to ill health.
