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For the purpose of predicting gene function based on 'guilt by association' with known genes in some process, the connectivity of a gene to a process was assessed as follows.
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A gene ontology analysis assigned three of the five annotated genes to a biological process (one gene per category): rhythmic process (corrected hypergeometric p<0.01), signal transduction (corrected hypergeometric p<0.05), and transcription (corrected hypergeometric p<0.05).
Physical interactions can link a gene product to processes based on the roles of interacting partners.
These results demonstrate the usefulness of the PIE approach to assess the biological coherence of a set of genes and the potential to use general PPI networks in an exploratory manner to predict genes of relevance to a process being studied.
At the extreme, a gene may have a GO annotation to a process such as 'DNA replication', but since this process is essential to life, the related phenotype is 'inviable'inviable
Such physiological generation of PTC could be a mechanism to regulate gene expression, a process termed regulated unproductive splicing and translation (RUST).
No longer will science and medicine proceed with deep uncertainty over how many genes relate to a particular process.
"Gene drive," a process that makes all offspring inherit a gene instead of the usual 50percentt, was used to show it was possible to spread an anti-malarial gene in mosquitoes.
Cloning is a prerequisite for genetic engineering, the process of altering or adding genes to an embryo.
Twenty-two patients with the condition, treated at six centers around the world, underwent so-called gene therapy, a process in which the normal variant of a gene is inserted into the patient's DNA, compensating for the abnormal one.
We conclude that psb28 from T. pseudonana is a gene in the process of endosymbiotic gene transfer.
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