The phrase "a gene down" is not standard or widely recognized in written English.
It may be used in specific contexts related to genetics or biology, possibly to indicate a mutation or alteration in a gene.
Example: "The research indicated that the mutation resulted in a gene down, affecting the organism's development."
Alternatives: "a gene mutation" or "a gene alteration".
The two panels agreed if both panels called a gene up-regulated or both panels called a gene down regulated.
Methylation shuts a gene down.
Efforts to identify genes on human chromosome 21 with the potential to cause the brain anomalies observed in Down syndrome (DS), led to the discovery of a gene, Down syndrome candidate region-1 (DSCR1) now renamed RCAN1 (Regulator of Calcineurin-1).
First, we repeated the experiments from Figures 1 and 2 for h 2 = 0.5, but reducing the proportion of causal SNPs from all SNPs within a gene, down to 50%, 10 % and 1 (always using at least one SNP).
A comparison between Cold/Light and moderate high light responsive gene expression [4] is indicated after description of the gene: (UP); a gene up regulated under moderate high light, (Down); a gene down regulated under moderate high light and ; no change in the gene expression under moderate high light.
For instance, among the transcripts involved in cytoskeleton organization, cell shape and differentiation, we identified Pdlim4/RIL, a gene down-regulated in H-ras transformed cells [36], which forms with ALP, Elfin and Mystique the ALP subfamily of PDZ-LIM proteins [37] and is a regulator of actin stress fiber turnover [38].
An example of a gene down-regulated in both rats and human PAs is Dlk1, encoding a non-canonical ligand of Notch.
To be physiologically relevant, modifications in gene expression observed in p8-/ liver after LPS have to be significant compared to normal wild-type liver (e.g.: a gene down-regulated by a factor of 2 in p8-/-, compared to wild-type, must be up-regulated at least 4 times after LPS to be physiologically significant).
The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments.
A global gene down-regulation was observed across the 14 days of in vitro differentiation and down-modulation of the TGFbeta signaling pathway, together with involvement of several important mediators like AKT1 and SMADs proteins, were defined as crucial events.
As expected, GK islets showed an up-regulation of ACE, AGTR-1 genes but an AGT gene down-regulation, which could be linked to the local insulin inhibitory effect on AGT mRNA expression in EC [100].
