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However, while this was a game-changing statement, there is still a long way to go before the Vatican's teachings on condoms meet the needs of Catholics around the world – for contraception as well as for HIV and Aids prevention.
It's being seen as a game-changing statement of intent from Spotify, which is looking to divert more of its focus away from the competitive world of music streaming, and into the growth industry of podcasts.
Major League Baseball offered a game-changing statement of support through social media yesterday for GLAAD's annual Spirit Day, asking fans to take a stand on bullying against lesbian, gay, bisexual and transgender (LGBT) youth.
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In a statement on Saturday, Mr. Paul's campaign promoted what they called a "game-changing" and "consequential" endorsement that Mr. Paul would receive Sunday evening.
"He's been a game-changing CFO, but he's also so much more than that," Moonves said in a statement.
"This discovery dramatically shifts the known time frame of a game-changing behavior for our ancestors," Dr. Zeresenay Alemseged, who led the team, said in a statement.
That was a game-changing performance.
"This is a game-changing deal".
"It's a game-changing offer".
This is a game-changing announcement.
It was, predictably, a game-changing decision.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com