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The results reported here suggest that longer term exposure of D-cells to gastrin and G-Gly also stimulates a further negative feedback loop by enhancing subsequent somatostatin release thus providing a means to restrain acid hypersecretion caused by hypergastrinaemia and control longer term acid secretion.
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NF-κB further initiates a negative feedback loop toward its own activity by inducing the expression of IκB subunits and the NF-κB inhibitor A20 [ 172, 198].
Skipping one class leads to more worry and sadness, which leads you to feel overwhelmed, which prevents you from getting to your next class, and this just further creates a negative feedback loop.
The magnitude of further possible negative feedback effects can only be guessed at".
In addition, we found that adding a positive (not necessarily essential) loop to a model architecture based on a negative feedback loop further increases robustness and the allowable range of parameter variation.
It has been postulated that release of NO upon platelet activation acts as a negative feedback to further platelet activation/recuitment, thereby raising the threshold of stimulus necessary to cause aggregation, and helping to prevent inappropriate thrombus formation.
A positive feedback accelerates a temperature rise, whereas a negative feedback decelerates it.
This response provides further support of an intact negative feedback mechanism in the ARC of hpg females, despite the lack of developmental reproductive hormone exposure.
SOCS proteins are transcriptional targets of STATs and function in a classic negative feedback loop to inhibit further STAT activation by interacting with either JAK catalytic or receptor sites (Starr and Hilton, 1998, 1999).
This may be due to the effect of a negative feedback as a result of further reduction in E2 levels upon the introduction of an aromatase inhibitor.
Such a reduction could be explained by a negative feedback mechanism whereby exenatide inhibited further GLP-1 release from L-cells.
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