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Our results add a further complexity in this process.
Besides age-related tissue specific transcriptome changes, our analysis also identified a further complexity in the relationship between aging and certain biological processes such as oxidative stress response and immune response.
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A further complexity suggested in this study is the differing interprofessional positions.
A further complexity arises in that some of these types of damage are reversible (notably cataract and band keratopathy) leading to the slightly bizarre scenario that their correction has to be specifically prohibited within most clinical trials.
A further complexity concerns the manner in which HMGB1 stimulates inflammation.
This study has revealed a further complexity to the role of cofactors in the propagation of prions.
Another aspect of IGF-R is the formation of IGF-1R/IR hybrids by random association of insulin half-receptor (IR-A) with an IGF half-receptor adding further complexity in receptor targeting strategy [ 119].
Thus, the addition of further complexity in an ACT featuring response-adaptive randomization of participants to what appears to be the more effective arm or explaining fixed-interim analysis could appear to increase the complexity of informed consent decisions [ 31].
However, in the spinal cord, prostaglandin-induced hyperexcitability was enhanced by EP1 receptors but reduced by an EP3α agonist (ONO-AE-248), suggesting further complexity in the prostanoid regulation of pain [ 57].
More than one GPCR may participate in rapid oestrogen signalling, and it is likely that further complexity in oestrogen-mediated GPCR signalling may occur as a result of coupling of different G protein heterodimers with the same receptor.
To judge whether Solo Uno is worth $100, look for further complexity in two years.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com