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This hierarchy supports the dualism between mind and body that is deeply correlated with gender asymmetry, and that was a fundamental target of critique in the development of feminist perspectives in philosophy.
Equipping students with the competence to construct explanations scientifically is also a fundamental target of science education (Kultusministerkonferenz 2004; Ministry of Education, P. R. China 2011; NGSS Leading States 2013).
Finally, although miR-25 has also been reported to exert antiapoptotic effects via interference with the expression of proapoptotic proteins, such as Bim [ 22], TRAIL [ 23], and PTEN [ 24], these results show how MCU can be considered a fundamental target of miR-25-dependent apoptosis inhibition.
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As such, understanding the specific role of mitochondrial dysfunction in cancer pathogenesis may be an interesting and fundamental target for new anticancer therapies and preventing or limiting the onset of conventional drug resistance in cancer patients.
The club's fundamental target this season is still just to stay in the top flight and safeguard the revenue streams that will allow them to make further progress in the next one.
This fundamental target incorporates several other advantages, such as: reduction of process variability, quality improvement in the finished product and the possibility to focus the design of mechanical devices on functional features, eliminating technical constraints imposed by the process.
The role of protein kinase-based signaling pathways in controlling phenobarbital-mediated induction of CYP450s had been proposed, even before CAR was recognized as the fundamental target of phenobarbital.
Finally, if Austin viewed the locutionary act rather than the illocutionary act as the fundamental target of assessment as to truth, then it would be difficult to understand Austin's treatment of performative utterances in the context of his distinction between locutionary and illocutionary acts.
"The fundamental target is the regime, because its fall will mean the end of all this chaos," Khaled al-Hammad, secretary-general and head of Jabhat al-Asalah wal-Tanmiyyah, told VICE News.
In these pathologies the skeletal muscle is the fundamental target.
Several biologically fundamental target processes responsive to 4‑HNE signaling have been identified, including modulation of apoptosis, activation of stress response pathways, cell proliferation and differentiation, mitochondrial coupling, and others (reviewed in refs. [ 9, 15- 18]).
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