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The phrase "a fundamental problem with" is correct and usable in written English.
It can be used when discussing a significant issue or challenge related to a particular subject or situation.
Example: "There is a fundamental problem with the current approach to climate change that needs to be addressed."
Alternatives: "a core issue with" or "a key challenge regarding".
Exact(59)
There is a fundamental problem with the idea, however.
"I think there's a fundamental problem with philanthropy," Hayman says.
"There's a fundamental problem with the F.H.A.," Mr. Pinto said.
Bernard Jenkin, the committee chairman, said he thought there was "a fundamental problem" with Heywood's investigation.
There seems to be a fundamental problem with the design of the project here.
The theory also solves a fundamental problem with the Higgs boson.
Rather, it reflects a fundamental problem with the contemporary Republican Party.
The scene is endearing, sad and funny, yet it underscores a fundamental problem with "Ruins".
But "Scotland's Future", as it is titled, reveals a fundamental problem with the independence pitch.
But more important, Mr. Alan said, he had a fundamental problem with a park-and-ride station.
"It's a precautionary move," Mr. Dulaney said, "rather than any indication of a fundamental problem with the business".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com