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The phrase "a fundamental intermediary" is correct and usable in written English.
It can be used to describe something or someone that plays a crucial role in facilitating or connecting two parties or processes.
Example: "In the negotiation process, a fundamental intermediary is essential to ensure that both sides reach a mutually beneficial agreement."
Alternatives: "a key mediator" or "a crucial link".
Exact(1)
Moreover, the last four steps, involving the ancestral copies of the extant ArgB, C, D, and LysZ, Y, J, K, may have been able to recognize different substrates and to catalyze their conversion into ornithine, a fundamental intermediary in arginine biosynthesis.
Similar(59)
In addition, AA are fundamental intermediaries for the tricarboxylic acid cycle [ 8].
A fundamental rethinking?
That's a fundamental conflict.
This is a fundamental change".
That is a fundamental fact.
"That is a fundamental difference.
Listening underwent a fundamental change.
That's a fundamental problem".
We had a fundamental disagreement.
This is a fundamental misapprehension.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com