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The phrase "a fundamental difference that" is correct and usable in written English.
You can use it when discussing a significant distinction or contrast between two or more subjects.
Example: "There is a fundamental difference that separates the two theories in their approach to understanding human behavior."
Alternatives: "a key distinction that" or "a crucial difference that".
Exact(3)
It's not clear exactly what this means for brain development, it just points to a fundamental difference that needs more exploration.
A more recent work, MMRate [19], is built on a similar idea as Topic Cascade with a fundamental difference that the topic of a cascade is viewed as a latent factor and needs to be estimated.
For him, this is a fundamental difference that impacts how he thinks about the user experience.
Similar(57)
That's a huge fundamental difference that affects everything about the way a company operates.
Let's break down the value components of SFRs versus CRE and explore the single fundamental difference that is a unique and primary driver of value for CRE.
To policy analysts, the notion of collective ownership over PrEP's benefits to Australian society is one fundamental difference that has avoided its controversial introduction in places like the US.
Frank then pointed to a more fundamental difference that benefitted Reagan's anti-government conservatism.
Dr. Baker says the polysynthesis parameter is the most fundamental difference that languages can have, and it cleaves off Mohawk and a few other languages -- for example, Mayali, spoken in northern Australia -- from all others.
Other factors are at work, as well, including one fundamental difference that lawmakers of both parties say lies at the heart of their competing philosophies.
Although L. variegata was involved in both circumstances, there are several fundamental differences that probably contribute to the different outcomes.
Wesabe is best described as a web version of Quicken, but with some fundamental differences that make all the difference in the world.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com