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"a fundamental difference between" is a perfectly correct and usable phrase in written English.
You can use it when two things have a significant contrast between them. For example: "There is a fundamental difference between the political beliefs of Democrats and Republicans."
Exact(60)
It's a fundamental difference between what we believe.
There is a fundamental difference between my opponent and me.
There's a fundamental difference between gothic ruins and modern ruination.
But there is a fundamental difference between Toyota and Intermountain.
"There is a fundamental difference between cows and screwdrivers.
This illustrates a fundamental difference between Bob Dole and Bill Clinton.
But there was a fundamental difference between these beloved men.
But there is a fundamental difference between religion and religiosity.
But in either case, it marks a fundamental difference between the tickets.
For the Mets, there is a fundamental difference between this winter and last.
"There is a fundamental difference between my opponent and me," Mr. Bush said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com