Sentence examples for a fundamental defect from inspiring English sources

The plan "is full of good intentions," the Turin daily La Stampa wrote in a front-page editorial on Wednesday, "but it has a fundamental defect: It doesn't give more funding for the education and training of young Italians".

We speculate that reduced proliferation and vascularity in Perk-deficient insulinomas is caused by a fundamental defect in function in the secretory pathway that we have recently discovered in beta-cells.

Insulin resistance (IR) represents a fundamental defect in type 2 diabetes and precedes the disease for many years (2).

First, it has been suggested that dysfunctional β-cells present a fundamental defect in the pathway responsible for processing of proinsulin to insulin (18).

Hyperglycaemia associated with the morning meal has been shown to be a fundamental defect that is especially marked in patients with HbA1c levels between 7% and 8%11.

The lack of response may reflect a fundamental defect in the proposed mechanism of action or inadequacy of exposure (dose), frequency, or timing of the investigational drug.

Some economists believe the worst is over and that the recent setback was caused mainly by a need to "correct" excess inventories, not any fundamental defect in the economy.

This is why I said earlier that insulin resistance may be a fundamental underlying defect in many cancers, as it is in type 2 diabetes and heart disease.

Histological examination of paraffin sections showed that none of the ViaatlacZ -/- newborns examined had inflated their lungs at birth indicating an early fundamental defect in respiratory function (data not shown).

In this letter he wrote, "The fundamental defect is a want of power in Congress…the confederation itself is defective and requires to be altered; it is neither fit for war, nor peace".

The introduction of ivacaftor as a mutation-specific treatment that addresses the fundamental defect in people with the Gly551Asp mutation has been hugely exciting for patients with cystic fibrosis and clinicians alike.