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In a consequence, choosing a threshold for converting mRNA levels of the studied genes into the binary results appeared to be a fundamental challenge when higher specificity resulted in lower sensitivity.
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More importantly, insulator surfaces pose fundamental challenges when aiming for on-surface reactions.
A fundamental challenge in digital control arises when the controlled plant is subjected to a fast disturbance dynamics but is only equipped with a relatively slow sensor.
This clinical scenario, particularly when played out in the ICU, reflects a fundamental challenge to the multidisciplinary health-care team: getting the whole team to play from the same page of music.
So when Jason Kincaid says Tim O'Reilly says Steve Jobs is trying to build a fundamental challenge to the Web, I have to be careful.
A fundamental challenge in the design of Wireless Sensor Networks (WSNs) is to maximize their lifetimes especially when they have a limited and non-replenishable energy supply.
"We face a fundamental challenge in economic reform," Turnbull said.
Fashioning Betty Boop as a mascara spokeswoman presented a fundamental challenge.
"A fundamental challenge of this process is how to preserve the artery and veins," he said.
I'm thinking of this as a fundamental challenge to my concept of holidays.
It's political in the broadest possible sense, a fundamental challenge to life in the city.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com