The functionality context of a feedback loop is defined as a set of constraints on the values of the external regulators of that loop [ 83].
Noteworthy, if p16INK4a is maintained at a positive level (1 or 2), this functionality context is stable when DSB=SSB = 0 and indeed, there is multi-stability under this stress condition, with two stable states differing by their values of the circuit members.
GINsim provides the functionality context (if not empty) of each circuit.
The functionality context of the positive auto-regulatory circuit is defined by ERK = 0.
The functionality context of the negative circuit corresponds to IKK = 1 (which is the case when TNFα is 1).
Similarly, the simulation of ERK ectopic expression, disrupting the functionality context of ph auto-regulation, leads to the loss of the multi-stability when EGF = 0.
The functionality context of each feedback loop in the logical model was identified on the basis of the logical model with the JAVA tool GINsim 2.4 alpha[ 84].
To help analyse these properties, GINsim identifies all the regulatory circuits embedded into a network and compute the regions of the state space, called functionality contexts, where they generate the related property (multi-stability versus oscillations).
Overheads can include node discovery, context aware functionalities (context gathering, maintenance and distribution), cluster functionalities (cluster formation, cluster maintenance, etc).
Entailing a set of advanced computational functionalities, context-aware applications are able to, by relying on context knowledge, control over processes and automate operative tools as well as provide services and support decision-making needs, thereby exhibiting intelligent behavior.
