While this comparison allows several evolutionary conclusions (see below), the P. pacificus data set on its own can be used as a starting point for a functional analysis of the dauer stage and dauer exit.
The results also provide a valuable resource as a starting point for future functional research on the specific hemolymph proteins or pathways related to the differential phenotypes or physiology.
Nonetheless, we can further narrow our criteria for site prediction expecting that in the case of the Epd data, sites predicted with a more stringent PP (i.e., > 0.9) be in fact functional divergence-related sites that can serve as a discrete starting point for future functional characterization of the Epd proteins.
These hypothesized functions may serve as a starting point for further functional studies in the respective organs.
Inspecting genome databases and expression arrays (of an enzyme, transporter, receptor or ligand) without their integrative functional knowledge with respect to various forms of arthritis will be a starting point for functional genomics in this area.
At this point, these analyses comprise a standard methodology that we routinely apply as part of larger projects, often as a starting point for functional studies in the wetlab or as a part of a Mendelian randomization study.
Additional ShortRead functionality is a starting point for downstream analysis.
However, these studies offer at best only a starting point for functional studies focused on a smaller subset of genes.
Although several studies have profiled changes in gene expression during normal retinal development, these studies offer at best only a starting point for functional studies focused on a smaller subset of genes.
Our findings suggest interesting links between regulation of gene expression mediated by nucleosome assembly/disassembly and various physiological and developmental aspects of the life cycle of plants, which may serve as a starting point for functional characterization studies for an important class of factors regulating chromatin dynamics – histone chaperones.
We suggest, when analyzing proteins in low throughput, to use remotely conserved HMMerThread domains as a starting point for functional prediction and – especially when looking at remotely conserved domains with very low sequence similarity – to proceed with an independent verification step.
