Identification of several hits in such a functional assay provides a good starting point for future characterization of the compounds by more phenotypic assays and for correlations of functional disturbances with, e.g., transcriptome changes.
Therefore, the comprehensive differential gene list together with the functional grouping, in particular, provided by this study offers a valuable resource and a starting point to explore extended functional networks, new targets or a specific novel pathway in greater detail related to small bowel inflammation.
A second in silico comparison was made using KEGG [ 12] functional annotations as a starting point.
While this comparison allows several evolutionary conclusions (see below), the P. pacificus data set on its own can be used as a starting point for a functional analysis of the dauer stage and dauer exit.
The results also provide a valuable resource as a starting point for future functional research on the specific hemolymph proteins or pathways related to the differential phenotypes or physiology.
Nonetheless, we can further narrow our criteria for site prediction expecting that in the case of the Epd data, sites predicted with a more stringent PP (i.e., > 0.9) be in fact functional divergence-related sites that can serve as a discrete starting point for future functional characterization of the Epd proteins.
The decoration of these building blocks with the needed functional sidechain is a good starting point for protein-protein interface inhibitors.
This clarification of the evolutionary relationships between Bce-like modules should provide a good starting point for functional studies as indicated below.
Cross-species functional analysis provides a good starting point to assist model species selection and recommends accurate novel paralogous genes in a flexible and alternative route for further investigation.
These hypothesized functions may serve as a starting point for further functional studies in the respective organs.
Inspecting genome databases and expression arrays (of an enzyme, transporter, receptor or ligand) without their integrative functional knowledge with respect to various forms of arthritis will be a starting point for functional genomics in this area.
