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The characterisation of EmTFP250 adds to the expanding apicomplexan TRAP family and suggests a functional significance for the protein.
This homodimerization mode may have a functional significance in redox modulation of HuR activity in response to oxidative stress.
However, based on our findings, TLR4 has a functional significance in EAU and further study of TLR4 and innate immunity will enhance our understanding of the EAU pathway.
Here, we show using the HSPA5 inhibitor - epigallocatechin gallate (EGCG) that the chaperone is essential for virus infection, thereby demonstrating a functional significance for the association.
The presence of inflammatory cytokines, photoreceptor mitochondrial oxidative stress, and mtDNA damage before leukocyte infiltration during early EAU, suggests that the role of innate immunity, especially TLR4, has a functional significance in the EAU pathway.
Together, these data suggest a functional significance of chromosome positioning.
Has this kind of organisation a functional significance?
We plan to investigate whether there is a functional significance of this phenomenon.
Further studies should elucidate whether duplicated GABA receptor subunits have a functional significance for GABAergic transmission in fish.
Our results demonstrate that the global gene expression in ES cells is propagated to the protein level, which may have a functional significance.
Here we show that VEGF and VEGFR-2 are co-expressed in MPNST cells and that VEGF triggers signal transduction suggesting a functional significance.
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