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This indicates that there might perhaps be a functional selection against variations, acting on TM domains of monoamine receptors, which is less selective on the TM domains of peptide receptors, and chemokine receptor GPCRs.
To further increase the GT efficiency we applied the bi-partite approach, in which the DNA fragment for integration was split in two non-functional overlapping parts that via homologous recombination in vivo can form a functional selection marker.
Unlike gene duplication, gene loss is not an unspecific mechanism but is rather influenced by a functional selection.
Growth can only be restored when the plasmid integrates by a single homologous crossover into the genome, which results in a functional selection marker and a copy containing both mutations.
On the other hand, 16 genes were significantly hypermethylated in DKO cells, indicating that these loci might retain methylation due to a functional selection pressure, which is consistent with a recent study [ 28].
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Google ships a small but functional selection of watch faces with Android Wear.
This could indicate a lack of functional selection pressure.
Conditional Ka/Ks combines the benefits of correlation analysis (detection of interactions between sites) with the benefits of standard Ka/Ks (a measurement of functional selection pressure).
The data on distribution of editing sites among codon positions, codons, and genes as we presented above demonstrate clearly that fixation of editing sites and fixation of mutations at editable sites followed a pattern of functional selection.
Expert knowledge was integrated into the biomarker identification process using the combination of two distinct approaches; a distance-based clustering approach and an expert knowledge-driven functional selection.
We also identified a stepwise pathway towards functional selection in evolving genes by alternative splicing.
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