No evidence of gain of function has been reported, but it is plausible, because a functional screen of the PARK2 splice variants has not been done yet.
Engineering such a probe requires a functional screen of many candidates.
Therefore we performed a functional screen of 12 SARS-CoV-encoded proteins to identify any potential modulators of MAVS-induced apoptosis.
IL (interleukin -34 was interleukin -34n additional ligand through a functional screen of extracellular proteins [ 14].
The lncRNA BCAR4 was discovered in a functional screen of ZR-75-1 breast cancer cells to identify mechanisms of anti-estrogen resistance [ 92].
In a functional screen of Uromyces viciae-fabae, secreted peptide effector protein UF5 was related to the flax rust Melampsora lini haustorial-expressed secreted protein HESP-379 [ 16].
A recent study by Davis et al., in which a functional screen of all the non-synonymous variants of a newly discovered gene was performed, highlights the value and necessity of characterizing the functional consequences of each genomic variant discovered.
42 Obatoclax was developed from a lead compound identified in a functional screen of natural compounds that detected disruption of protein protein interactions between members of the BCL-2 family.
The first evidence of PARP-1's role in this reprogramming process came from a functional screen of epigenetic modification factors that identified PARP-1 as a potent inducer of OSKM-mediated iPSC generation.
