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These data support the notion of a functional relevance of integrin cytoplasmic salt bridge disruption during integrin activation.
This suggests a functional relevance of the 3'UTR sequence of Mitf.
Evidence for a functional relevance of this interaction is provided by partial co-localization in SH-SY5Y cells.
It is therefore reasonable to surmise a functional relevance of this structural conservation and, as an extension of that, a relationship between 3D architecture and transcriptional activity.
The reduced γ-secretase cleavage activity of Leu217 albeit albein in a substrate-specific manner, suggests a functional relevance of this polymorphism.
This corroborates a functional relevance of these lincRNA-related eSNPs.
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Moreover, it has been assumed that overlapping transcripts should have a functional relevance for regulation of gene expression [ 27- 31].
Nevertheless, the close timing correspondence between peak hyoid speed and laryngeal vestibule closure suggests a functional relevance for measures of hyoid velocity.
Given that both His170 and Trp319 were shown to be essential for the in vivo chaperone activity of CRT [15], [18], this raises the intriguing question of a possible functional relevance of such a proximity.
The results of our study demonstrate a complex transcript pattern for bovine skin and suggest a possible functional relevance of novel transcripts, including lncRNA, in the modulation of pigmentation processes.
In accordance with previous studies [ 27] our phylogenetic analyses of the BMP4 gene revealed a highly conserved sequence of the BMP4 region which would suggest a potential functional relevance of variation at this locus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com