The phrase "a functional relevance in" is correct and usable in written English.
It can be used when discussing the importance or significance of something in a particular context or field.
Example: "The study highlights a functional relevance in understanding the relationship between diet and health outcomes."
Alternatives: "a practical significance in" or "an operational importance in".
These results demonstrate that MAL-overexpression influences transcriptional regulation of most of the newly identified genes both in vitro and in vivo, suggesting a functional relevance in Schwann cells.
Although p33ING1 and p53 have a functional relevance in certain biological process, there are studies showing p33ING1 could exert a p53-independent function in apoptosis or cell growth inhibition.
In addition, TMEM27 has a functional relevance in beta cell proliferation and insulin secretion [ 19, 32], and, although its levels were found to be decreased in islets derived from diabetic donors compared with healthy controls, it was still present in these patients [ 33, 34].
Strikingly, RNAi-mediated repression of Atg5 or Atg7 (essential genes for autophagy) suppresses IL6/8 production, indicating a functional relevance of autophagy in senescence.
It should be noted that the conclusions presented here do not contradict a functional relevance of EDMs in POLE for carcinogenesis and predisposition to CRC as has for example been shown for germline mutations by Palles et al. [ 8].
Despite the low number of cases/controls investigated in this study, these results suggest a functional relevance of SNP rs6886 in OC and FTC.
A functional relevance, however, might exist in the context of persistence development.
Our data with two independent pharmacological NOX inhibitors therefore argue against a functional relevance of mitochondrial NOX4 in cardiac and renal mitochondria under physiological conditions.
Our results support a previous study, using a targeted mutagenesis approach [ 21], which showed that mutation R215W prevented the binding of NBN to γH2AX following radiation, and suggests a functional relevance for this mutation in protein-protein interactions.
This SNP genotype has been linked with worse prognosis among mCRC patients treated with chemotherapy with or without an anti-vascular endothelial growth factor antibody: our data confirm in primary tumors that the C allele is linked with increased EZH2 expression and activity, thus providing additional evidence for a functional relevance of this SNP in CRC biology.
Therefore, our observations on MUC4 HER2 interaction in SKOV3 have a strong functional relevance in ovarian cancer progression.
