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Overall, these results reveal a remarkable self-organization of corticofugal and callosal tracts with a functional output, providing new opportunities to examine relevant aspects of human CNS development and disease.
Such a functional output can be manifested by an increased transepithelial electrical resistance (TEER).
It has been demonstrated that D2R overexpression within the STR alters working memory, a functional output correlated with the prefrontal cortex.
As a functional output, we examined the activity of the cAMP-activated chloride channel, which is encoded by the CFTR gene.
and more novel phenotype markers (SphK1/2, FIZZ1 etc). in a time and stimulus dependent manner and to create a functional output with which to evaluate the neuronotoxic effects of phenotype.
tph-1 mutants showed diminished functional representation primarily due to loss of tph-1 as a functional output whereas daf-7 mutants showed diminished functional representation primarily due to increased variability in tph-1 expression.
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The fact that expression of a constitutively active ATF2 in Lrh-1 LKO cells facilitates ER stress resolution argues that ATF2 is a major functional output of PLK3 in ER stress resolution.
Accordingly, inhibition of JNK-2-3 nuclear translocation was described to protect from apoptosis in sympathetic neurons and CGCs Our results provide the first evidence that apoptotic and survival cues give rises to different site-specific configurations of c-Jun N-terminal multiphosphorylation, each having a different functional output in neuronal cells.
Facilitating or restricting access to DNA is an ultimate functional output of chromatin, and genome-scale information on DNA inaccessibility is needed for the interpretation of epigenome profiling studies.
In our system, however, human hepatoma and mouse colon cancer cell lines showed an opposite functional output of TGF- β and TNF- α crosstalk.
In conclusion, we have developed a versatile methodology for engineering cardiac tissues with a near-adult functional output without the need for exogenous electrical or mechanical stimulation, and have identified mTOR signaling as an important mechanism for advancing tissue maturation and function in vitro.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com