Sentence examples for a functional importance of from inspiring English sources

The fundamental role of the octanoyl chain on Ser3 and the aromatic group of Phe4 in membrane-binding strikingly resembles the importance of these two residues for ghrelin function, suggesting a functional importance of ghrelin binding to membranes.

As these observations point to a functional importance of BicD phosphorylation, we set out to study the molecular basis of this phenotype.

The present results may point to a functional importance of the pri-miRNA-126 SNP.

STMN1 overexpression will partially rescue cells from miR-101-mediated inhibition of autophagy, indicating a functional importance of this target.

Recent data suggest a functional importance of the PAI-1 4G/5G polymorphism, which could have a neuroprotective effect through increased astrocytic expression of PAI-1 [ 19].

Taken together, these results demonstrated a functional importance of HDAC4 in miR-10b-mediated response of ER-positive cells to tamoxifen treatment.

However, a functional importance for any of these identified genetic anomalies requires further investigation in breast cancer.

The integrated approach is applicable both to cell line models in vitro and to patient-derived samples ex vivo; for a given cancer cell model, it provides a functional importance scoring of the drug targets, according to an estimate of how much the cell sample is addicted to the particular target protein.

In general, selection acts in genomic regions that have a functional importance, thus, identification of genes that have undergone recent selection or that are currently under selection is relevant [ 77].

The position of the turns appears to be evolutionary conserved among different species, as shown by a multiple sequence alignment of seven vertebrate shrew-1 homologues, suggesting a fundamental functional importance of this region (Suppl. Figure S1).

Correlation analyses identified an E1-I2 length-correlation in Group O and Group J and an N-E3 length-correlation in Group J. Taken together, these results suggest a possible functional importance of LT length in the GPCR superfamily.