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The possibility to put a function or a functional element (logical nodes or logical devices) in a test mode.
ENCODE adopted a strong version of the causal role definition of function, according to which a functional element is a discrete genome segment that produces a protein or an RNA or displays a reproducible biochemical signature (e.g., protein binding).
"APIs are not a book, not a play, not a song, not a poem," he said – just a functional element that allows developers to access source code.
It wants to make GCSE maths and English tougher by bringing a "functional" element into the exams.
Sometimes a functional element is everything they need – but at other times it might be a spaceship, a doll's house, a telescope, a video game controller or a swim fin".
Each functional element is tested according to a functional element test plan, with a top-down strategy.
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For example, for non-coding regions, we could further exploit the sequence context of a variant to identify a possible functional element (e.g. a non-coding RNA site) and use this information to improve predictive accuracy.
However, the fabrication of optrodes, a key functional element in optogenetics, remains a great challenge.
In S. cerevisiae, however, the conserved function of CD5 is executed by two independent snoRNAs, snR72 and snR78, with a single functional element [ 48].
However specific lipid-mediated interactions at the T cell plasma membrane bilayer are also a central functional element in early TCR signalling.
For instance, a sudden decrease of heterozygosity around position 15000 could be related to the presence of a putative functional element, such as gene regulatory region or functional noncoding RNA (fig. 4 A ).
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