Exact(2)
The conservation of repeats within the chloroplast genomes of all algal taxa suggests a functional constraint for these structures.
Because of this, he regarded the reduced foraging efficiency as a functional constraint for evolving disproportionately long proboscides.
Similar(58)
Thus, a functional constraint at protein level for this gene overlap can be excluded.
The compensatory mutations in the stem regions do, to some extent, covary and this is considered further evidence for a functional constraint on pDo500 satellite DNA.
Alternatively, rapid evolution may be due to a lack of functional constraint; for example, a pseudogene rapidly accumulates mutations because of an absence of purifying selection.
Coding fRNAs may have a stronger effect on evolutionary rates at synonymous sites than at nonsynonymous sites, because there are many more sources of functional constraint for nonsynonymous sites, thus requiring a survey with greater statistical power to understand the more subtle influences of coding fRNA on nonsynonymous rates.
The optimal value for ω was < 1 in all pairwise comparisons (Table 1) suggesting that the transferred genes may have been under functional constraint for some period of time before they lost function.
The lower density of indels in the 5'UTRs than in the 3'UTRs suggests that functional constraint for insertions and deletions is higher in the 5'UTR regions than in the 3'UTR regions.
This might have been one functional constraint for the co-evolution of the YY1 binding motifs within the protein-coding potential of the OLFR genes.
The problem is in the practical detail: How do we know that there is no functional constraint for query sequences (whether there is convergent evolution or common ancestry)?
The importance of differences in functional constraint for rates of protein evolution has long been recognized (Kimura 1983), and purifying selection is clearly an important determinant of rates of protein evolution (Charlesworth B and Charlesworth D 2010).
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