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As the DH and KR domains are functionally redundant within the LM, this does not indicate a functional constraint imposed on this pairing, but does suggest that the AT-III and DH domains 'move' as a group.
One way to handle this problem is to impose a functional constraint in which the least eigenvalue of the matrix is non-negative.
This configuration cannot be broken up without a loss of regulatory inputs and constitutes a functional constraint on genome rearrangement.
Overall, our results suggest that even if most of the sites are subjected to purifying selection, which is suggestive of a functional constraint, the presence of several sites with Ka/Ks>1 indicate that the F-orf-vd1 is a fast evolving gene in the Mytilus F genome.
This could be indicative of a functional constraint.
Thus, a functional constraint at protein level for this gene overlap can be excluded.
Similar(33)
Therefore, we can test a hypothesis that a particular feature of a network necessarily requires a particular functional constraint to be present during growth.
This poorly conserved footprint could be identified by manual editing of a multiple sequence alignment performed with clustalW, thus indicating a lower functional constraint on MIR168b as compared to MIR168a transcription.
In addition, we enforce a novel functional constraint corresponding to the relative ordering of attractor states in BN models to restrict the space of BN models to the biological relevant class.
Maximum likelihood analyses of dN/dS ratios for the aligned coding region sequences among 14 primate species indicated that PCSK9 was subject to a strong functional constraint (i.e., purifying selection).
Those are likely to indicate a common functional constraint ("gatekeepers").
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com