Collectively, we have provided a functional compartmentalization overview and an organizational framework of intracellular Rab-mediated vesicle trafficking that can serve as a resource for future investigations.
Despite these major differences between nuclear landscapes of different myelopoietic cell types at a global scale, we noted a consistent organization between all cell types at a more local scale with regard to a functional compartmentalization into an active and an inactive nuclear compartment (ANC and INC).
Thus, there may not be a requirement for functional compartmentalization of specific loci or chromatin domains at this stage.
This can be considered as a form of functional compartmentalization of Cx37.
Numerous studies have reported that pollen tubes and root hairs, two tip growing plant cells, display a structural and functional compartmentalization of their cytoplasm and their organelles, which is thought to be essential for tip growth [ 15- 19].
Studies on the composition, structure and behaviour of speckles have provided a model for understanding the functional compartmentalization of the nucleus and the organization of the gene-expression machinery splicing snRNPs and other splicing proteins necessary for pre-mRNA processing.
Further studies in this field would be helpful to form an integral concept of the structural and functional compartmentalization of the nucleus as well as to extend our knowledge on the mechanisms of early embryogenesis in mammals.
Consistent with a key role of the blood brain barrier in the functional compartmentalization of the brain pH during and after asphyxia was that, when plotting brain extracellular pH against body pH, a profound hysteresis was observed (Fig. 3A).
Additionally, the spatial organization of the eukaryotic genome is linked to the functional compartmentalization of the cell nucleus.
Chromosome domains and their topology, in addition to other functionally relevant nuclear landscapes (e.g, transcription foci, RNA processing, DNA repair), point to the importance of functional compartmentalization of the nucleus [6].
