These data are consistent with the in vitro observations that cyclin D1 can be stringently regulated as a function of subcellular localisation (Alt et al, 2000; Radu et al, 2003) and reveal that distinct localisation patterns are observed in prostate cancer.
The main objective of this work was to probe the efficacy of NPs to amplify radiation effects as a function of their localisation in the cells.
Fluorescence microscopic analysis of tumour tissue, taken 5 min, 2, 6 and 24 h after administration of the compounds, revealed a shifting pattern, as a function of time, in the localisation of labelled lipoproteins and hypericin.
The rationale for the new model is based on the hypothesis that long-term stabilization of carbon in soil is mainly a function of its accessibility or its localisation within the soil pore space.
Figure 7 shows the localisation data calculated using an ROA as a function of detection performance (collapsed across radiologists and images) for trials on which detection plus localisation were correct (blue bar), the additional localisation correct trials produced by including a ROA (dark grey bar) and detection only trials on which localisation was incorrect (light grey bar).
These comprise source localisation using two-dimensional acoustic array measurements and assessment of the wayside noise increase as a function of the speed.
20 Substitution at either the C2 or the C5 carbon atoms (Scheme 1) of the PNA backbone with amino acid side chains leads to ambivalent structures with the properties of a DNA or RNA mimic on one hand and of a peptide mimic on the other, thus allowing recognition by specific receptors, as shown very recently by a short PNA mimicking the function of a nuclear localisation signal peptide (NLS).
We suggest a number of factors that can lead to an underestimation of localisation information such as image variability, the precision of localisation responses and correct detection guesses.
To test the hypothesis that CCP proteins possess an ancestral ciliary function, localisation of three proteins from this subset was examined in T. brucei cells.
While tBRD-1 required tTAF function for nucleolar localisation, localisation of tTAFs, TAF1 and Polycomb to the nucleolus was not visibly altered in homozygous tbrd-1 mutants when analysed by immunofluorescence.
