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The lacZ transgenic mouse has been constructed so that every cell of the animal contains multiple copies of an integrated target reporter gene, allowing us to measure tissue-specific radiation-induced changes as a function of dosing regime.
Indeed the tolerability and the efficacy of chemotherapeutic drugs, as well as of radiotherapy, vary 50% of more as a function of dosing time in mice or rats (Lévi, 2001).
Survival curves also differed significantly as a function of dosing time.
The effect of CDDP addition on gemcitabine was further investigated as a function of dosing time.
Cosinor analysis did not show significant circadian rhythms in area under the curves (AUCs) of the compounds as a function of dosing time (P ≥ 0.1354).
Similar(55)
Tumour size was compared as a function of dose and dosing time before mortality from tumour progression.
Thymus area declined logarithmically and medullary cysts increased as a function of dose (P≤0.05).
Results showed that DNA damage occurs as a function of dose, of kinetic energy and of LET.
A large number of products were observed on the chromatograms, their composition changed gradually as a function of dose.
The MAE at three chosen lattice sites as a function of dose is shown in Fig. 12.
No consistent changes in vital signs occurred as a function of dose or time after study drug.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com