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Time constants for activation and deactivation were determined and plotted as a function of command potential (Fig. S1), showing that β4 slowed both the activation and deactivation time course.
The extent of gating charge return during hyperpolarization was quantified as mean IgOFF / IgON as a function of command voltage.
(G ) Mean steady state current after break-in plotted as a function of command voltage (n = 4).
Figure plots peak inward current as a function of command voltage for 10 WT DRG neurons without and with application of 20 mM Cs+. (B ) Inward current as a function of command voltage is displayed for 10 dKO DRG neurons without and with Cs+.
(C ) The difference between peak inactivating current and steady-state current at 20 ms is plotted as a function of command voltage for the different recording times, revealing little change in Na+ current over the 30 min of recording.
Boltzmann fits yielded, for control solution, Vh = −10.1 ± 0.4 mV with z = 4.1 ± 0.4 e ; with 20 mM Cs+, Vh = −15.9 ± 0.2 mV with z = 3.7 ± 0.1 e. (D ) Mean Nav conductance was plotted as a function of command potential for 10 dKO DRG neurons and fit with a Boltzmann function.
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Based on the reduced models, several cases of numerical simulation of the unit operation have been conducted to monitor the evolution of the unit operation as a function of its command parameters and external perturbations.
To express P win and temporal discounting D as a function of the control command u, we first assume hyperbolic temporal discounting, D u) = 1/(1 + kT u)) [ 12].
(What's more as I wrote earlier this year the increasing distance of his ideas from the images that convey them is also a function of his increasing technical command).
In sharpest possible contrast to those earlier tributary arrangements, however, modern command societies have virtually all been organized in the name of socialism that is, with the function of command officially administered on behalf of an ideology purported to serve the broad masses of the population.
The likelihood term P t (c| p) indicates the probability of performing the command c at time t, if the demonstrator were to perform the program p. This probability is time-dependent and is modeled using a PDF as a function of t and the motor commands c.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com