Our results demonstrate that p53 plays a key role in regulating lincRNA-p21 transcript levels in response to UVB in keratinocytes and that lincRNA-p21 has a critical function in triggering apoptosis in UVB-treated keratinocytes.
Thus, it is likely that in addition to their role in innate immunity, TLRs serve an important function in triggering signaling pathways leading to establishment of humoral immunity.
Our results indicate that oxytocin might have more than merely an all-or-nothing function in triggering milk ejection.
The major genetic risk factor continues to be shared epitope-expressing HLA-DRB1 alleles, which function in triggering the TCR.
Besides their function in triggering apoptosis, ROS may function as important signalling molecules in starvation-induced autophagy, and it was recently shown that ROS production induced by NADPH oxidase activates antibacterial autophagy in phagocytes, suggesting a role for NADPH oxidase in autophagy regulation.
As in animal cells, intracellular free Ca2+ in plant cells, is a key actor in regulatory functions, playing a major role in triggering various endogenous and exogenous signals to cellular responses.
Our data suggest that T. brucei ARL6 has spatial and functional similarities to ARL-3A and there may conceivably be an association between the two proteins, either in function or in triggering activation.
The induction of both apoptotic and partly necrotic responses in the bladder carcinoma cells reflect the effects of cis-UCA treatment on cellular metabolism, as mitochondrial functions play a central role in triggering of both apoptotic and necrotic cell death.
This solution seems much reliable, despite the fact that some recent studies also found an autophagy-independent function of Atg5 in triggering death of cell [ 98].
This observation, combined with the known function of p53 in triggering apoptosis, led us to propose the model illustrated in Fig. 10.
Later, the essential function of osteoclasts in triggering inflammatory bone erosions was shown by blocking essential molecules for osteoclastogenesis or by using mice deficient in osteoclasts [ 10, 11].
