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Pulmonary hypertension and poor myocardial function often play a role in the pathophysiology of pulmonary disease [ 1].
Altered serotonin transporter (5-HTT) function also is thought to play a role in the pathophysiology of MDE (Cannon et al. 2006b; Stockmeier 2003).
These two different phenotypes possess different functions in the pathophysiology of sepsis.
NO plays an essential role in regulating airway function and in the pathophysiology of inflammatory airway diseases.
Nitric oxide (NO) may play an essential role in regulating airway function and in the pathophysiology of inflammatory airway diseases [ 1].
blood-brain barrier plays a key role in the pathophysiology of brain function, stroke, and dementia [ 32– 32].
Given its importance, alteration of ICNS function is thought to play a central role in the pathophysiology of heart failure and arrhythmias [ 15, 44, 45].
Hypogonadism is believed to play a major role in the pathophysiology of ED, with a minimum threshold testosterone level required for normal erectile function.
Chronic sleep restriction (such as self-imposed short sleep duration) plays a pivotal role in the pathophysiology of overweight and obesity via the modulation of neuroendocrine function.
Renal function is closely related to organ blood flow and changes in perfusion are considered to play a key role in the pathophysiology of renal disease [ 5].
Moreover, H2S also plays a key role in the pathophysiology of endotoxin, septic and haemorrhagic shock [ 13], vasorelaxation [ 19], inflammation [ 14, 20] and cardiac function in rats [ 21].
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