Sentence examples for a function assignment from inspiring English sources
This could be an example of how a function assignment based on the sequence and structure similarity (InterproScan) could actually be different from a function assignment based not only on the structure but also on the physical/chemical and functional biological properties (Protfun).
Clear orthologous relationships were observed in further occasions, providing the basis for a tentative function assignment to Daphnia homologues of SUR, a membrane receptor regulating a potassium channel, and to Daphnia homologues of the Drosophila genes ET23 and scarlet.
The expected average number of matching of the proteins in <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0017679.e165.PNG" class= inline-graphic"/> for a random function assignment is 25.
As a consequence, function assignment through homology may lead to erroneous or incomplete annotations and therefore, requires immense caution for structure-based functional assignment.
To compare our results with a recent function assignment scheme, we adopt the hypergeometric test used in Ref. [ 23] ('CYC2008' dataset) and applied the method with the same threshold (E-value = 0.05) to our dataset.
In addition, PlasmoDB was searched for proteins carrying a Gene Ontology molecular function assignment [ 81] of 'protein kinase activity' (GO 0004672).
As a consequence, the function assignment by iGA is very sensitive [ 26] compared to methods which use a predefined correlation cut-off.
Schork et al. [ 46] used a relatively simple SNP function assignment method based on considering the functional setting of SNPs in LD with GWAS markers and looking for category enrichment for 14 complex traits.
Such functional diversity within a homologous protein family presents a significant challenge for bioinformatic function assignment.
Classification schemes provide a guideline for systematic function assignment to proteins.
Many sulfhydrolases have a domain composition very similar to that of EC:4.4.1.1, which makes a definitive in silico function assignment to any of them difficult.
