A fully integrated model can overcome compartmentality in the assessment process and provides opportunity for a better integrative exploratory planning process.
This leads to high degree of flexibility in signal distribution and allows, for the first time, the construction of a fully integrative discrete dynamic model of TGF-β signaling pathways.
As a step towards an integrative model of DNA-damage response pathways to better cover the onset of senescence, our model focuses on G1/S checkpoint enforcement.
However, there remains a critical gap between an integrative model of "omics -data and clinical variables.
From this point of view, a more integrative model of KMC, ED, LC and innovation performance is offered.
In the sixth section, a conceptual, integrative model of auditory processing of multi-talker speech is presented.
The outdated dictum "first prolong life, then improve quality of life" should be replaced by a holistic, integrative model [ 6].
This classical model is being progressively substituted by a much more integrative model of signal transduction, in which a considerable amount of cross-talk takes place between pathways.
Figure 3 shows an integrative model for a light-induced effect on breast cancer etiology [adapted from Stevens (2005)].
Here, we will introduce a novel and integrative model of macrophage activation.
