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With a fully integrated modelling framework, both the benefits and risks of a different dosing strategy can be explored, which is of special importance in oncology where a range of outcome measures are being applied and different types of adverse effects are limiting.
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Creating a fully integrated model using specific solution algorithms.
A fully integrated model can overcome compartmentality in the assessment process and provides opportunity for a better integrative exploratory planning process.
These are the following: Link independently developed top-down and bottom-up models Incorporation of technological detail into a top-down framework or macroeconomic feedback into a bottom-up framework Creating a fully integrated model using specific solution algorithms.
In the present work, we have developed a new formalism, CADBIOM, based on guarded transitions and combined discrete abstraction to propose, for the first time, a fully integrated model for TGF-β signaling pathways.
When data from component studies are available, using all data in a fully integrated model-based framework is in general more efficient than a sequential approach using summary statistics only.
We plan to soon present a fully integrated model for malaria in humans and mosquitoes that will include realistic health-systems settings to examine combinations of vector-control interventions with other malaria-control interventions and provide further outputs, such as effectiveness in reducing morbidity and mortality and cost-effectiveness analysis.
(2005) suggest the term "embedded" to classify solutions which fully integrate modeling functionality in one independent piece of software.
This work addresses this gap by examining the operational flexibility of supercritical coal power plants with amine based CO2 capture, using a rigorous fully integrated model.
This fully integrated model resolves a complex interplay between heat transfer at the macroscale and grain structure evolution and microsegregation formation at the mesoscale.
Attention problems, insomnia and early alcohol intoxications did not show statistically significant associations with suicidal thoughts in the fully integrated model.
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