The neuronal ceroid lipofuscinoses (NCLs) represent the most frequent group of inherited neurodegenerative diseases in children, with an estimated worldwide incidence of 1 14,000 to 1 67,000, depending on ethnic group and the founder group effect (Santavuori, 1988; Haltia, 2006; Mole et al., 2011).
The most frequent group of symptoms was musculoskeletal problems, followed by asthenia/fatigue.
The most frequent group of mitochondrial diseases results from genetic defects of the oxidative phosphorylation system (OXPHOS) [ 2].
The majority of trials evaluated medications (Table 4) with analgesics and sedatives being the most frequent group of drugs evaluated (8%).
In Europe, mood disorders are the second most frequent group of mental disorders, dominated by MDD, which affects 7% of the population [ 2].
Patients presenting with non-painful articular impairment from cluster 4 were the second most frequent group of patients who were referred for or who sought treatment for TMD.
Complications were observed in 28 of the 99 patients (28.3%) and the observed sum of events was 68 (Table 2).> The most frequent group of complications were infections, diagnosed in 24.2% of the patients.
The third most frequent group of SNP markers, 13 of 203 (7%), increases the TBP binding affinity for core-promoters of human genes and, hence, causes overexpression of these genes.
Autosomal recessive (AR) ataxias are the most frequent group of inherited ataxias with onset in childhood, particularly Friedreich ataxia and Ataxia-telangectasia. Different criteria have been used to classify these forms.
The second most frequent group of factors associated with PSDs were factors that are psychosocial problems themselves, e.g. psychopathological symptoms, global disability and functioning, emotional problems, or cognitive deficits.
