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In spite of a frequent expression of Fas/CD95 in high-grade gliomas, these tumours are typically refractory to conventional therapy.
We detected a frequent expression of CT7 in primaries and corresponding metastases (55%) as well as for CT10 (30%).
In this study, we analysed the expression of CT7 and CT10 in 54 MM samples and detected a frequent expression of CT7 in primaries and corresponding metastases (55%) as well as of CT10 (30%).
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Of these 64, respectively 11 and 6 miRNAs fall into regions of focal recurrent amplifications and focal recurrent deletions, pointing towards a frequent expression perturbation of these miRNAs as result of underlying DNA aberrations.
However, only a trend for a more frequent expression of P-170 was found in the leukaemic cells of patients who experienced relapses (P = 0.099).
Cross et al. observed a more frequent expression of RANKL in estrogen negative patients with a high histologic grade breast cancer.
Moreover, we found a more frequent expression of PRL-3 in lymph node metastases as compared to the primary tumours (91.7 vs 66.7%; P=0.033).
Sotelo et al. found HLA DQ2/DQ8 haplotypes in 11 out of 15 children with CD in Northern Mexico [ 16] and Cerda et al. found a more frequent expression of DQ8 haplotypes in adults with CD [ 17].
The sensitive NSCLC (CIM areas M and O) were characterised by a less frequent expression of drug resistance proteins than resistant tumours of CIM areas D and F. On the other hand, these resistant tumours revealed a lower expression of proliferation/angiogenesis-regulating proteins (CIM area E) compared to sensitive tumours (CIM area N).
As shown for other tumour entities, we have found a significantly more frequent expression of PRL-3 in lymph node metastases as compared to the corresponding primary tumour.
Controversially, Maubant et al. [ 30] found a significantly less frequent expression of the β3 subunit in grade 3 ovarian tumours compared to grade 1 and 2 tumours, and less expression in peritoneal metastasis compared to primary tumours.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com