However, this study suggests that subcellular localization may also be a fairly frequent event for other transcription factor transcripts, providing a unique way to temporally and spatially coordinate the functions of otherwise independently regulated genes (Lecuyer et al. 2009).
Whereas loss of Bax is a frequent event in human cancer, for example, in colon cancers having a microsatellite mutator phenotype, Bak expression persists in most cancers and loss of both is a rare event.
It appears that functional redundancy among CDKs and cyclin-binding partners is a frequent event bringing clear implications for the clinical utility of pan-CDK inhibition (Aleem et al, 2005; Cai et al, 2006).
See related commentary by Peñuelas et al., http://ccforum.com/content/15/2/128 Unplanned extubation (UE) is a frequent event after endotracheal intubation for respiratory support in critically ill patients and is associated with increased morbidity and mortality [ 1- 12].
In agreement with the methylome study by Martinez et al. [ 3], where the significance of GATA6 methylation in patient survival has been shown for the first time, our results suggest that the methylation of GATA6 is a frequent event and highly important for survival of patients with glioblastoma.
Retinal detachment was a frequent event in the follow-up course for patients in both groups.
The results presented here demonstrate that DUB dysregulation is a frequent event in cancer, and have implications for therapeutic approaches based on DUB inhibition.
Loss of PTEN expression is a frequent event in NPC [ 46], accounting for the extensive deregulation of cellular signaling pathways (e.g. PI3K/AKT/mTOR and Wnt) and the metastatic propensity via induction of the epithelial-mesenchymal transition phenotype.
However, recurrence is still a frequent event after optimal cytoreduction and IPCH for CRPC [ 28], and the modalities are still investigational and do not endorse extended applications outside of a clinical trial.
Overexpression of ERα can be caused by estrogen receptor 1 (ESR1) gene amplification and was originally reported to be a frequent event associated with a significantly longer survival for ER-positive women treated with adjuvant tamoxifen monotherapy, which was however questioned by subsequent studies.
