Comorbidity is a frequent challenge for clinicians, and transdiagnostic approaches may assist the clinician to emphasize underlying processes which may be shared across disorders (Fairburn, 2011; Mansell, Harvey, Watkins, & Shafran, 2009).
A frequent challenge in these kinds of experiments and validations is the lack of a stable, reproducible and flexible biological reference material.
The main argument was that extra-articular manifestations are rather frequent in AS and the entire spectrum of spondyloarthritis, 39 and that they constitute a frequent challenge in management that clearly requires cooperation between specialities.
The LED-based microscopes (CY and PiLED) on the other hand are structurally built to overcome the hard operational environment of RLS where continuous supply of electricity, sufficient equipment and trained personnel are a frequent challenge.
Ventilating obese patients is becoming a frequent challenge since the prevalence of obesity is steadily increasing and reaching epidemic proportions worldwide [ 14, 15].
Consistent production of solid drug materials of desired particle and crystallographic morphologies under cGMP conditions is a frequent challenge to pharmaceutical researchers.
A further clear advantage of muscle as target tissue is the lower risk of vector dissemination compared, e.g. with liver and the finding that pre-existing anti-AAV humoral immunity, a frequent challenge for AAV-mediated gene therapy, does not block transduction (reviewed in Mingozzi & High, 2013).
The accurate changepoint detection of different signal segments is a frequent challenge in a wide range of applications.
Imaging of the degenerative spine is a frequent challenge in radiology.
Addressing delusions presented by patients in the first meeting is a frequent challenge in acute care.
They each address problems of complexity, which is a frequent challenge in global health.
