As report author Dr Windsor Holden says, "Apple has been able to achieve several billion downloads from a comparatively small handset base because customers are buying the iPhone for the apps… So even if you have a subscriber base of tens of millions, your addressable market is a fraction of that – and spread across a variety of operating systems and handsets".
Expression of HA-Rap1V12, HA-hRap1B-retro and HA-mRap1A-retro1 induced a clear increase in the fraction of spread cells.
Using a chi-square test (df 2) the fraction of spread nuclei that display strong, weak or negative Rts1 with respect to Ndc10 was compared between wild-type and CUP-CLB3 χ = 54.49, p<0.0001.
Using a chi-square test (df 1) the fraction of spread nuclei that were Rec8 positive or negative was compared between wild-type and ndc80-1 χ = 1.185, p=0.2764 and between CUP-CLB3 and CUP-CLB3 ndc80-1 χ = 23.96, p<0.0001.
Using a chi-square test (df 2) the fraction of spread nuclei that display colocalized, partial or mislocalized Mam1 with respect to Ndc10 was compared to wild-type: CUP-CLB4, χ = 2.554, p=0.2788; CUP-CLB3, χ = 39.31, p<0.0001.
For bottom panel, using a chi-square test (df 2) the fraction of spread nuclei that display strong, weak or negative Rec8 with respect to Ndc10 was compared between wild-type and CUP-CLB3 χ = 121.2, p<0.0001.
For top panel, using a chi-square test (df 2) the fraction of spread nuclei that display strong, weak or negative Rts1 with respect to Ndc10 was compared between wild-type and CUP-CLB3 χ = 18.02, p=0.0001.
For (C ), using a chi-square test (df 2) the fraction of spread nuclei that display colocalized, partial or mislocalized Lrs4 with respect to Ndc10 was compared between wild-type and ndc80-1 χ = 0.9668, p=0.6167 and between CUP-CLB3 and CUP-CLB3 ndc80-1 χ = 56.34, p<0.0001.
The fraction of spread nuclei that display colocalized, partial or mislocalized Lrs4 with respect to Ndc10 was compared to wild-type using a chi-square test (df 2): CUP-CLB4, χ = 1.136, p=0.5666; CUP-CLB3, χ = 45.84, p<0.0001.
For (G ), the fraction of spread nuclei that display colocalized or mislocalized Sgo1 relative to Ndc10 was compared between wild-type and CUP-CLB3 using a chi-square test (df 1) χ = 1.554, p=0.2125.
