The phrase "a formidable problem in" is correct and usable in written English.
It can be used when discussing a significant or challenging issue within a specific context or field.
Example: "Climate change presents a formidable problem in environmental science that requires urgent attention."
Alternatives: "a significant challenge in" or "a serious issue in".
In 2011, after a prominent security and anti-corruption expert was killed by motorcycle hitmen, Honduras banned motorcycle passengers all together.While he admits that motorcycle crime is a formidable problem in Argentina and the region, Juan Belikow, an Argentine security expert, has little faith in Mr Scioli's new rule.
Drug resistance remains a formidable problem in managing cancer patients.
Although researches have advanced greatly in MDR, it remains a formidable problem in clinical treatment.
This study provides evidence that GBV remains a formidable problem in Thai Nguyen province with serious reproductive health consequences for the women who live there.
As the recurrence and metastasis of HCC remains a formidable problem in clinical practice, many efforts have been made to develop a more efficient treatment to inhibit or prevent tumor metastasis.
Numerous evidences showed that chemoresistance is a clinically formidable problem in managing EOC patients.
Neuronal replication, in contrast to DNA replication (Figure 1), is a formidable problem, mainly because the p-bond connectivity in the latter is one-dimensional, in contrast to being two-dimensional in the former.
The combination of the divine and the human in Jesus posed a formidable problem for 2nd-century theologians, especially the Gnostics, who adopted a cosmological dualism and held that the material world was the creation of the Devil.
Resistance to third-generation cephalosporins in gram-negative nosocomial pathogens is a formidable problem, associated with adverse clinical outcomes and increased hospital costs (1 – 4 ).
As accounting for the former is quite a formidable problem, we estimate the mean value < L > at different moments in the course of the substorm.
Despite recent evidence suggesting some improvement in outcomes over time [ 2, 3], AKI remains a formidable problem.
